USP <1229.2> is titled Moist Heat Sterilization of Aqueous Liquids. This chapter discusses the sterilization of items such as in-process aqueous liquids, suspensions, laboratory media, and biological waste materials. As described by USP, “sterilization of liquids in containers is accomplished by application of heat to the container, heating of the container wall, and ultimately heating of the internal liquid volume. This can be accomplished using steam, superheated water, and air in various combinations.” Care must be taken, though, to make sure the containers chosen are able to withstand the conditions they are exposed to.
The topics covered in this chapter of USP include:
- Terminal Sterilization of Products
- In-Process Fluids
- Laboratory Media
- Biowaste Sterilization
- Bioburden/Biological Indicator Method
- Bioburden Method
- Sterilization Cycle Control
- Validation of Liquid-Filled Container Sterilization
- Routine Process Control
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